G4TV interviewed Chris Metzen to learn about the story background of Diablo III. Those who haven’t played Diablo games before won’t feel left out. The story compels newcomers to learn more about the Diablo universe and past in general through in-game books, and quests.
G4TV also has other Diablo III Press Event videos to consider watching:
Chris sounds so tired in this interview.
On top of crunch-mode on Diablo III, the Diablo III: Book of Cain, he also has 3 days of Press Event interviews. Of course he got to be tired. =)